The Rams (1-0) host the Giants (0-1) tonight for Monday Night Football. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 8:15 p.m. ET. MNF will broadcast live on ESPN and ABC.
The Rams are 6.5-point favorites over New York on the spread (Rams -6.5; -118) and the over/under is 47.5 (-110o / -109u). The Rams are -320 favorites on the moneyline and the Giants are +250 underdogs.
Continue below for our Monday Night Football best bets and Giants vs Rams picks, which include the spread, over/under and player props for Blake Corum (receptions), Darnell Mooney (receptions) and Isaiah Likely (anytime touchdown).
Giants vs Rams Against the Spread Prediction
By John Lanfranca
It may feel like taking the Giants +6.5 at this point is getting the worst of this line for Monday night football, but I still show some value on the road team given the circumstances.
Puka Nacua is trending in the wrong direction and the Rams' passing game would take a major hit if he is out or limited in a significant way. This would translate to a run-heavy gameplan that will cause Los Angeles to have long-sustaining drives that take plenty of time off of the clock.
Speaking of methodical drives, the Giants had four scoring drives of 10 or more plays in Week 1. This is how the New York offense will operate in 2026.
Greg Roman has his fingerprints all over the scheme being operated and it is the exact style of play head coach John Harbaugh is looking to make this team's identity.
Jaxson Dart is getting the ball out of his hands more quickly this season as the coaching staff is emphasizing his protection. The Rams failed to record a sack against the 49ers and I don't see this as being the week their pass rush gets on track.
The Rams offense is short-handed and their defense will struggle to find opportunities to disrupt Dart inside the pocket. In addition to all of this, the Rams were gashed by the 49ers in the running game to the tune of 5.5 yards per carry.
New York is carrying confidence and momentum into a showcase game that can prove it will be a true contender this season. I expect them to make this a highly competitive game that goes down to the wire.